Development And Validation Of Spectrophotometric Method For Estimation Of Antineoplastic Agent Anastrozole In Bulk And Tablet Dosage Form

Mrityunjay Banerjee

Abstract


A Simple U.V. Spectrophotometric method was developed for the estimation of Anastrozole in bulk and tablet dosage form by using 1N HCL.The maximum absorbance (λmax) was found to be 205.9nm.The calibration curve was in concentration range 8-18µg/ml with correlation co-efficient of 0.999.The procedure was validated as per ICH rules for accuracy, precision, detection limit, linearity, reproducibility and quantitation limit. The percentage recovery for Anastrozole was found to be 99.80% to 100.10%.Due to its simplicity, rapidness, high precision and accuracy of the method it may be used for determining Anastrozole in bulk and tablet dosage form.


Keywords


Anastrozole,U.V.Spectrophotometry,1N HCL.

References


Plourde.P.V,M.Dyroff,M.Dukes. Breast cancer Res.Treat.30,103(1994).

Tripathi KD. Essentials of medical pharmacology. 6th ed.Jaypee publication, New Delhi,306(2008).

Dixon JM,Jackson J,Hills M,Renshaw L.Cameron DA, Anderson TJ,Miller WR, Dowsett M Eur.J.Cancer 40, 2742 (2004).

Agorastos T,Vaitis V,Pantazis K,Efstathiadis E,Vavilis D,Bontis JN Eur J Obstet Gyneol Reprod Biol 118, 239 (2005).

Mouridsen HT,Robert NJ Eur J Cancer 41, 1678 (2005).

Freeman S.A,Modesitt SC Gynccol Oncol 103, 755 (2006).

Mauriac L Best Pract Res Clin Endocrinal Metabol 20 15 (2006).

Sathis Kumar D, Harani A, Rohit reddy T, Sucharitha G, Krishna. P1, Priyanka sagar J, International journal of advances in pharmaceutical sciences, 1 (2010), p. 329 - 333.

SMITA SHARMA, MUKESH CHANDRA SHARMA, Journal of Optoelectronics and Biomedical Materials Vol.2 Issue 4, October – December 2010, P. 217 – 221.

Arvind G Jangid, Ashutosh M. Pudage, Santosh S. Joshi, Pramod N. Pabrekar, Vikas V. Vaidya, Biomedical Chromatography, Volume 24, Issue 7 pages 727 – 731, July 2010.

Apostolou C, Dotsikas Y, Kousoulos C, Loukas YL., 18657375 [PubMed-indexed for MEDLINE] .

Block, Beale, ed. “Wilson and Grisvold’s text book of organic medicinal and pharmaceutical chemistry”, 11th edn, Lippincott company, 2004, page – 437.

Sethi P.D., “Quantitative analysis of drugs in pharmaceutical preparations” 3rd edition, CBS Publishers, New Delhi, 1997, page – 285.

Merck Index. 13th edition, Merck and co., Inc, 2001 P-105, M No- 632.

D. SRINIVASULU, B.S. SASTRY, S.A SUNIL, H. RAMANA, International Journal Of Pharmacy and Pharmaceutical Sciences, Vol 2, Suppl 2, 2010.

A.S. Zidan, O.A. Sammour, M.A. Hammad, N.A. Megrab, M.J. Habib and M.A. Khan, Journal of microencapsulation, 2008, Vol. 25, No. 3, Pages 145-153.

WWW.ScienceDirect.com

WWW.drugs.com

www.rx list.com

Perumalla Bharati, Arya Vinodini, Ala Shiva Reddy, and Potturi Sita Devi, JPC- Journal of planar chromatography, Modern TLC, Volume 23, Number 1/February 2010

Ahmed S. Zidan, Omaima A. Sammour, Mohammed A. Hammad, Nagia A. Megrab, Muhammad D. Hussain, Mansoor A Khan and Muhammad J. Habib, AAPS ParmSciTech 2006; 7 (3) Article 61 (http://WWW.aapspharmscitech.org).

D.SRINIVASULU, B.S. SAATRY, S.A.SUNIL, H. RAMANA, International Journal of Pharmacy and Pharmaceutical Science, Vol 2, suppl 2,2010.

G. Saravanan, M. V. Suryanarayana, Manoj J. Jadhav, M. Ravakumar, N.Someswararao and p. v. R. Acharyulu, chromatographia,vol.66,no.5-6,pg.435-438.




URN: https://pmindexing.com/index.php/IJCPA/issue/view/urn:pmi:jr:0011ijcpa.v5i2.14436

DOI: https://pmindexing.com/91.1211/ijcpa.v5i2.1443

Refbacks

  • There are currently no refbacks.