SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL EVALUATION OF BENZOTRIAZOLE DERIVATIVES

Mopuri deepa

Abstract


Four novel benzotriazole (B2T-1-4) derivatives are synthesized, characterized by the IR spetra and screened for anti-bacterial activity by Agar diffusion method. The synthetic scheme of benzotriazole involves the reaction between substituted benzotriazole with chloro acetyl chloride result into 1-H-benzotrizole-1-yl acetyl chloride.The formed 1-H-benzotrizole-1-yl acetyl chloride was further treated with amine derivative resulted in 4-[(1H-benzotriazole-1-yl acetyl)amino] benzoic acid. Finally fused with various aromatic amines to give four novel benzotriazole derivatives. The compounds shown the mild to moderate anti-bacterial activity when compared to standard Ampicillin.


Keywords


Benzotriazole, heterocyclic azoles, IRspectra,antibacterial activity.

Full Text:

PDF

References


Alan R, Katritzky, J org chem 1994 59(80), 5206-5214 DoI-10.1021

Andzelika Najda-Bernatowicz , In SYNLET 2009 P 625-627

Asati KC., Jouneral pharmacy research in 2006 vol-7 page 47-52

Balalaie Tetrahedron Letters 48 (18), 3299-3303, 131, 2007,

Cappello B,Chemical society 1993 c, 742-747

Chavon Renee to University Florida in 2003, C R Wikerson, purl-fcla.edu

Chung-Yi Wu, in ISSN 2005, 7, 1679

David G Leppard and co-inventors, US patent 1991 5,070.007

Fatima Al-Omran, J.Heterocycle chem.2002, 39, 877, 28

Giuseppe Caliendo, European J.pharm sci 2002, 16, 15

Helmute Prestel and Muller Klaus, US patent number4, 999,433, in 1991

Hironori Oda in, Dyes and pigments 2008 vol 76 p270-276

Jagattaran Das et al in, ISSN 2277-4327 in2005

Jiu Fu,ISSN 1600-5368 in 2010 Vol.65 Part 3 Page507

Jun Wan and coworkers PMCID in 2010, 66 pt 12: 03173

Kamal M. Dawood and coworkers in Research Gate in 2006, 99(2):189-195

Koen HG, chemistry and biology 2008 vol-15 issue6 p-597-606

Kuo-Long Yu in org Lett 2003, 1483-1486

Katarzyna K in, structure report in 2004vol-62 part-2

Lestaw Sieron Wydanie pierwsze, Blackhorse, Warszawa 2008

Maria B. Journal of Applied Psychology, vol 90, 2005,

Matilde CVN and Thomas Heinze Afr J Pure Appl Chem 4(8):142-51. In 2010,

Mervin Wood US Patent 6,800,676, Oct 2004.

Ming Jen Cheng Social Science Research 39 (6), 1047-1058, 2010.

Namdeo KP , CSIC in 77(16) pp 6917-6928 2009

Nanjund Swamy S Indian J, Pharm Sci, 2006

Norah B and coworkers in Journal of Higher Education, Volume 79,pp. 540-563 2008,

Purohit M and Srivastava SK IndianJournal of Pharmaceutical Sciences Volume 54 | Issue 1 1992

Pallav D. Patel et al the American Journal of Human Genetics

Biophysical Volume 17 in 2010,

Paolo Sanna US Patent 4,560,465 in 2000

Peter Ackerman and Max Schellenbaum in (Patent No: 5,322,853 Dated June 21, 1994).

Petr S, Hana S and Ivana C Patent No: 5, 322, 853, 2010.

Peter Ackerman and Max Schellenbaum in, Patent No: 5,322,853 Dated June 21, 1994.

Petr S, Hana S and Ivana C Patent No: 6,148,923, 2010.

Reneta Farkas Central European Journal of Chemistry, 2010,

Ravindran Durai Nayagam, logo 2009 volume-68, part-8, page 2399

Shukla DK and Srivastav SD Journal of Solid-State Circuits, 35(3):412– 4242008,

Stefanie Bovens and co investigators Aesthetics and Art Criticism 46:41–49 in 2009

Stephen DP procured United States Patent bearing No: 6,774,238 B2, dated Aug 10, 2004

Stephen DP procured United States Patent bearing No: 7,148,274 B2, Dec 12, 2006

Deepa Mopuri, G.Mahaboob Basha, P.Neelaphar, B.VinolyJeevan, Synthesis, Characterization And Biological Evaluation Of Some Novel 1, 3, 4-Trisubstituted Pyrazolyl Chalcones For Their Antimicrobial And Anti-Inflammatory Activities, J Global Trends Pharm Sci 2016; 7(2): 3176 – 3182.




URN: https://pmindexing.com/index.php/IJCPA/issue/view/urn:pmi:jr:0011ijcpa.v5i1.13767

DOI: https://pmindexing.com/91.1211/ijcpa.v5i1.1376

URN (PDF): https://pmindexing.com/index.php/IJCPA/issue/view/urn:pmi:jr:0011ijcpa.v5i1.1376.g11222

DOI (PDF): https://pmindexing.com/91.1211/ijcpa.v5i1.1376.g1122

Refbacks

  • There are currently no refbacks.